Collection

Lipids in Cell Biology

Submission status: Open
Submission deadline: 03 September 2025

Cells require lipids to maintain their integrity and separate cellular functions for appropriate homeostasis and regulation. Advances in lipid detection methods and techniques to probe lipid functions continues to uncover roles beyond containment, from organelle morphology, metabolic signaling, cell death, and energy metabolism. This collection invites submissions from all disciplines with insights into lipid function, regulation or detection.

Nature Communications and Communications Biology will consider original Articles, Reviews and Perspectives. Scientific Reports will consider original Articles.

To submit, see the participating journals

Nature Communications

ER-mitochondria contacts mediate lipid radical transfer via RMDN3/PTPIP51 phosphorylation to reduce mitochondrial oxidative stress

Mitochondria-ER contacts are an organelle exchange site for lipids and ions, but their regulation is not well understood. Here, Isshin et al. find that RMDN3 transfers lipid radicals, generated by mtROS, from mitochondria to the ER at contact sites to reduce toxicity to the cell.
- Isshin Shiiba
- Naoki Ito
- Shigeru Yanagi
ArticleOpen Access10 Feb 2025 Nature Communications
Endosomal trafficking participates in lipid droplet catabolism to maintain lipid homeostasis

Lipid droplets (LDs) and endosomes play crucial roles in cellular processes, yet their interplay is poorly understood. Here, the authors develop an LD-specific probe, AP1-coumarin, and reveal dynamic interactions between LDs and endosomes, regulating lipid homeostasis.
- Wang Peng
- Shu Chen
- Jianbo Yue
ArticleOpen Access24 Feb 2025 Nature Communications

Communications Biology

Palmitic acid induces lipid droplet accumulation and senescence in nucleus pulposus cells via ER-stress pathway

Lipid droplet and palmitic acid accumulation in intervertebral disc degeneration nucleus pulposus cells drive endoplasmic reticulum stress-dependent cellular senescence.
- Xi Chen
- Kun Chen
- Wenzhi Zhang
ArticleOpen Access7 May 2024 Communications Biology
Involvement of sphingosine 1-phosphate signaling in insulin-like growth factor-II/mannose 6-phosphate receptor trafficking from endosome to the trans-Golgi network

Continuous activation of the sphingosine 1-phosphate (S1P) receptor 3 (S1P3R) and subsequent downstream Gq signaling in the endosomes regulate the retrograde transport of the IGF-II/M6P receptors back to the TGN.
- Susumu Nishida
- Shubi Ambwene Matovelo
- Taro Okada
ArticleOpen Access19 Sep 2024 Communications Biology

Scientific Reports

Deficiency in NPC2 results in disruption of mitochondria-late endosome/lysosomes contact sites and endo-lysosomal lipid dyshomeostasis
- Raffaele Pastore
- Lihang Yao
- Radha Desai
ArticleOpen Access2 Jan 2025 Scientific Reports
Characteristics of different lipid droplet-mitochondrial contacts patterns during lipid droplet metabolism in T2DM-induced MASLD
- Ye Xu
- Yuan Zhang
- Jiao Lu
ArticleOpen Access27 Jan 2025 Scientific Reports

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Lipids in Cell Biology

Nature Communications

ER-mitochondria contacts mediate lipid radical transfer via RMDN3/PTPIP51 phosphorylation to reduce mitochondrial oxidative stress

Endosomal trafficking participates in lipid droplet catabolism to maintain lipid homeostasis

Communications Biology

Palmitic acid induces lipid droplet accumulation and senescence in nucleus pulposus cells via ER-stress pathway

Involvement of sphingosine 1-phosphate signaling in insulin-like growth factor-II/mannose 6-phosphate receptor trafficking from endosome to the trans-Golgi network

Scientific Reports

Deficiency in NPC2 results in disruption of mitochondria-late endosome/lysosomes contact sites and endo-lysosomal lipid dyshomeostasis

Characteristics of different lipid droplet-mitochondrial contacts patterns during lipid droplet metabolism in T2DM-induced MASLD