Game-based learning is redefining educational practices by integrating game mechanics—such as challenge, feedback, and narrative—into learning environments to enhance motivation, engagement, and knowledge retention. These approaches support active, personalized, and collaborative learning across diverse age groups and disciplines. This Collection invites original research on the design, implementation, and evaluation of game-based educational systems, aiming to advance pedagogical innovation and deepen our understanding of how playful experiences can drive meaningful learning outcomes.