The role of epigenetic mechanisms in cancer has gained interest in recent studies. The reversible nature of epigenetic changes on genomic DNA and histones holds promise for the development of therapeutic approaches and several of them have already been approved for clinical use. In addition, the study of epitranscriptomics, empowered by the detection for various RNA modifications, has revealed their pivotal role in diverse biological processes, whose deregulation has been implicated in several diseases including cancer. Targeting epitranscriptomic mechanisms can offer alternative avenues for improving cancer treatment efficacy.