RNA splicing involves the removal of non-coding introns and the joining of coding exons in precursor mRNA (pre-mRNA) to produce mature messenger RNA (mRNA). Splicing changes can lead to diseases, including various cancers, neurodegenerative disorders, and genetic syndromes converging on downstream signaling pathways. These disruptions often arise from mutations in splice sites, changes in splicing regulatory elements, or alterations in splicing factors. The therapeutic strategies have been developed to target splicing alterations.

This Collection welcomes original research on the mechanisms of RNA splicing, including research on new immunotherapeutic targets and splicing-related therapeutic approaches.